- Airlink – Bloemfontein and East London
- British Airways (operated by Comair) – Cape Town, Durban and Johannesburg: OR Tambo from Port Elizabeth Airport
- Mango – Cape Town and Johannesburg: OR Tambo
- South African Airways – Johannesburg: OR Tambo
- South African Express – Cape Town, Durban and Johannesburg: OR Tambo.
- Kulula – Durban, Cape Town and Johannesburg: OR Tambo
If you are looking for a domestic flight to or from Port Elizabeth Airport then you are able to book your flight with the Port Elizabeth Airport website. You will find the flight that you are looking for and book online so that the process is easy and hassle free.
Port Elizabeth Airport Airlines